Curcumin prevents and reverses murine cardiac hypertrophy
J. Clin. Invest. Hong-Liang Li, et al. 118:879 doi:10.1172/JCI32865 [
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Figure 7Curcumin ameliorates established cardiac hypertrophy. (
A and
C) Statistical results of HW/BW ratio, LW/BW ratio, and myocyte cross-sectional areas (200 cells per section) at 8 weeks after AB surgery (
A;
n = 5) or 3 weeks after PE infusion (
C;
n = 6). (
A) Mice began treatment with curcumin at 2 weeks after AB or sham surgery and then sacrificed 8 weeks later. (
C) Mice began treatment with curcumin at 1 week after PE or saline infusion and were sacrificed at 3 weeks later. (
B and
D) Gross heart and WGA-FITC staining of mice 8 weeks after sham or AB surgery (
B) or 3 weeks after saline or PE infusion (
D) treated with or without curcumin. Scale bars: 20 mm (gross heart); 50 μm (WGA stain). (
E and
F) Analysis of hypertrophic markers (
n = 4). Total RNA was isolated from hearts of the indicated mice, and expression of transcripts for ANP, BNP, β-MHC, and α-MHC induced by AB (
E) or PE infusion (
F) were determined by Northern blot analysis. *
P < 0.05 versus respective vehicle control.
