Curcumin prevents and reverses murine cardiac hypertrophy
J. Clin. Invest. Hong-Liang Li, et al. 118:879 doi:10.1172/JCI32865 [Go to this article.]

Figure 1
Pretreatment with curcumin inhibits cardiac hypertrophy in vitro. (A) Curcumin inhibited PE-induced [³H]leucine incorporation. (B) Representative fields of cardiac myocytes stained with α-actinin. Original magnification, ×200. (C) Quantification of cell cross-sectional area from experiments shown in B by measuring 50 random cells. (D) Curcumin blunted PE-induced ANP and BNP mRNA expression levels by Northern blot. [³H]leucine incorporation and Northern blot were measured as described in Methods. The results were reproducible in 3 separate experiments. *P < 0.05 versus control.