Impaired parasympathetic function increases susceptibility to inflammatory bowel disease in a mouse model of depression
J. Clin. Invest. Jean-Eric Ghia, et al. 118:2209 doi:10.1172/JCI32849 [
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Figure 6Influence of reserpine treatments (1 μg/d for 14 days) on MCSF-deficient mice. (
A) Macroscopic score, (
B) MPO activity, (
C) CRP level, and (
D) cytokine IL-1β level in colonic tissue after 5 days of DSS-induced colitis. Reserpine treatment (black bars) increased all 4 markers in +/? mouse but did not affect the op/op mice. Fold change is relative to op/op or +/? DSS 5% RM. *
P < 0.05,
n ≥ 8;
#P < 0.05 versus +/? DSS 5% control mice. The values are shown as means ± SEM.
