Impaired parasympathetic function increases susceptibility to inflammatory bowel disease in a mouse model of depression
J. Clin. Invest. Jean-Eric Ghia, et al. 118:2209 doi:10.1172/JCI32849 [
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Figure 4Influence of nicotine treatment on experimental depression and VXP. Influence of 10 days of nicotine (20 μg/ml in drinking water) treatments, starting 4 days after the beginning of reserpine (1 μg/d) treatment, on (
A) macroscopic score, (
B) MPO activity, (
C) CRP levels, and (
D) IL-1β cytokine levels in colonic tissue after 5 days DSS-induced colitis on RM (1 μg/d for 14 days) and nonreserpinized mice. Fold change compared with DSS 5% nonreserpinized mice. In presence or in absence of VXP, nicotine treatment significantly decreased all 4 markers. *
P < 0.05,
n ≥ 8. The values are shown as means ± SEM.
