Impaired parasympathetic function increases susceptibility to inflammatory bowel disease in a mouse model of depression
J. Clin. Invest. Jean-Eric Ghia, et al. 118:2209 doi:10.1172/JCI32849 [Go to this article.]

Figure 3
Effect of experimental depression on H&E staining. (A) Appearance of a colon in a DSS-treated nonreserpinized mouse. (B) Appearance of a colon in a DSS-treated RM; DSS treatment was associated with areas of greater erosion and with more inflammatory cell infiltration. (C) DMI treatment significantly reduced infiltration. (D) Following VXP, DMI treatment did not appear to result in any significant improvement. Images were taken after 5 days DSS induction of colitis on RM (1 μg/d for 14 days) and nonreserpinized mice. DMI treatment (15 mg/kg) was initiated 2 days after the beginning of the reserpine (1 μg/d) treatment. H&E staining. Original magnification, ×100.