Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats
J. Clin. Invest. Warner S. Simonides, et al. 118:975 doi:10.1172/JCI32824 [Go to this article.]

Figure 3
Inhibition of endogenous D3 activity with iopanoic acid for 6 h increases metabolic rate in isolated cells. Oxygen consumption (A and C) and extracellular acidification (B and D) in SK-N-AS neurons and NCLP6E hepatocytes that were propagated in media with (A and B) or without (C and D) a euthyroid concentration of T3 and exposed to iopanoic acid (Iop) versus vehicle control. Oxygen consumption rate (pmol/min/mg protein) and extracellular acidification rate (mpH/min/mg protein) are expressed as relative fold change from vehicle control. Values are mean ± SEM of 10 cell plates. *P = 0.07; **P < 0.05; ***P < 0.005.