Figure 1
Plg activation is required for macrophage recruitment.
(A) Macrophage recruitment in Plg+/+ and Plg–/– mice after thioglycollate injection (n = 3–7). (B) Recruitment of macrophages is suppressed in Plg–/– mice and enhanced in PAI1–/– mice (n = 9–22 mice per group). (C) Plg in plasma of Plg+/+ mice (n = 3) is unaffected by thioglycollate treatment. (D) Plasmin (83 kDa) activity in PLF was measured by casein zymography. (E) Intensity of plasmin bands in Plg+/+ PLF (3 independent assays). (F) Aprotinin and tranexamic acid (TA) reduce thioglycollate-induced macrophage recruitment in Plg+/+ mice (n = 8–10). *P < 0.05, **P < 0.01.
