Transplanted endothelial cells repopulate the liver endothelium and correct the phenotype of hemophilia A mice
J. Clin. Invest. Antonia Follenzi, et al. 118:935 doi:10.1172/JCI32748 [Go to this article.]

Figure 7
FVIII antigen in LSEC-transplanted hemophilia A mice and serial analysis of FVIII activity in cell recipients. (A) Hemophilia A mice 1 month after transplantation of FVB/N-Tie2–GFP LSECs with therapeutic correction. Neg Ctr, untreated hemophilia A mice. Each bar represents FVIII antigen level from an individual mouse after cell transplantation. (B) Plasma FVIII activity in hemophilia A mice after cell transplantation showing serial bleeding from 7 mice starting 2 weeks after surgery over a period of 60 days with therapeutic correction requiring more than 10% plasma FVIII. Mouse indicated as sham received vehicle alone.