The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity
J. Clin. Invest. Jun-ichi Hanai, et al. 117:3940 doi:10.1172/JCI32741 [
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Figure 2Lovastatin causes reduction in myotube diameter. C2C12 myotube morphology and mean diameter following treatment with lovastatin at various concentrations (
A) or for various times (
B). Control (0 μM) cultures were treated with reagent vehicle alone. Original magnification, ×100.