The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity
J. Clin. Invest. Jun-ichi Hanai, et al. 117:3940 doi:10.1172/JCI32741 [Go to this article.]

Figure 1
Atrogin-1 is induced in human biopsy samples from patients with statin-induced muscle injury. Total RNA was extracted from human quadriceps muscle biopsies, and atrogin-1 mRNA was quantitated by real-time PCR as described in Methods. *P = 0.017, difference between groups by 1-way ANOVA.