Secretoneurin promotes neuroprotection and neuronal plasticity via the Jak2/Stat3 pathway in murine models of stroke
J. Clin. Invest. Woei-Cherng Shyu, et al. 118:133 doi:10.1172/JCI32723 [Go to this article.]

Figure 6
SN administration i.v. enhanced the mobilization of stem cells in rats and mice. (A–L) In SN-treated rats 30 minutes after cerebral ischemia, a few BrdU-immunoreactive cells (arrows) were detected in the ipsilateral cortex near the infarct boundary (A–D) and subventricular area (E–H). (I–L) BrdU-immunoreactive cells were also found around blood vessels in the ipsilateral cortex. (M) Quantitative analysis revealed that the number of BrdU-immunoreactive cells significantly increased in the ipsilateral hemisphere of SN-treated rats compared with control rats. (N and O) Representative constructive images of IHC in GFP-chimeric mice showed significantly increased GFP⁺ cells over the peri-infarcted and striatal areas (white arrow) in the SN-treated mice compared with controls. Original magnification, ×30. Data are mean ± SEM. *P < 0.05 vs. control. Scale bar: 50 μm.