Secretoneurin promotes neuroprotection and neuronal plasticity via the Jak2/Stat3 pathway in murine models of stroke
J. Clin. Invest. Woei-Cherng Shyu, et al. 118:133 doi:10.1172/JCI32723 [Go to this article.]

Figure 5
SN reduces apoptosis by activating the Jak2/Stat3 pathway. (A and B) Two days after cerebral ischemia, the SN-induced reduction of infarct volume was blocked by infusion of the inhibitor AG490. (C) Representative image of TUNEL (green) and Hoechst 33342 (blue) costaining showing cell death in penumbrae of ischemic brains (arrowheads) from saline control and SN-treated rats. There were significantly fewer TUNEL-positive cells in SN-treated brain compared with saline control. Data are mean ± SEM. *P < 0.05 vs. control. Scale bar: 40 μm.