Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5
J. Clin. Invest. Fulu Liu, et al. 118:946 doi:10.1172/JCI32704 [Go to this article.]

Figure 3
Long-term d715 G-CSFR chimerism following G-CSF treatment is increased. Chimeric mice generated as described in Figure 1 were treated 5 months after bone marrow transplantation (BMT) with saline alone or G-CSF (10 μg/kg/d) for 21 days (indicated by the gray box). The percentage of circulating neutrophils (A) and B lymphocytes (B) derived from d715 G-CSFR cells was determined at the indicated times (n = 6–7 for each group). (C). Bone marrow was harvested from chimeric mice after treatment with G-CSF or saline and transplanted into secondary recipients (n = 5–10 each cohort of recipient mice). Shown is the percentage of d715 G-CSFR cells in the blood of the secondary recipients 4 months after transplantation. Data represent the mean ± SEM. *P < 0.001.