Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5
J. Clin. Invest. Fulu Liu, et al. 118:946 doi:10.1172/JCI32704 [Go to this article.]

Figure 2
The contribution of d715 G-CSFR cells to the KSL cell compartment is increased after G-CSF treatment. Chimeric mice generated as described in Figure 1 were treated with saline or G-CSF (10 μg/kg/d) for 21 days, and the percentage of KSL cells in the bone marrow derived from d715 G-CSFR cells was determined. (A) Representative scatter plot showing the strategy to identify KSL cells (boxed); data are gated on lineage^– cells (data not shown). (B) Representative scatter plots gated on KSL cells showing the percentage of d715 G-CSFR (Ly5.2⁺) cells. (C) The percentage of KSL cells derived from d715 G-CSFR cells is shown (n = 4–5 each). Data represent the mean ± SEM. *P < 0.001.