Adiponectin regulates albuminuria and podocyte function in mice
J. Clin. Invest. Kumar Sharma, et al. 118:1645 doi:10.1172/JCI32691 [
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Figure 3Adiponectin inhibits permeability across a podocyte monolayer. (
A) Permeability of albumin across a podocyte monolayer was reduced by gAd or fAd at 3 μg/ml (
n = 3 per group). Cells were treated as described in Methods, and permeability was assessed by albumin concentration across podocyte monolayer. Values (mean ± SEM) are presented as percent of control. *
P < 0.01 versus control. (
B and
C) Expression of AdipoR1 (
B) and AdipoR2 (
C) by real-time PCR in WT mouse liver, kidney, and differentiated podocytes. Values (mean ± SEM) are presented relative to β-actin and expressed as 100% in mouse liver.
