Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis
J. Clin. Invest. Shahla Abdollahi-Roodsaz, et al. 118:205 doi:10.1172/JCI32639 [
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Figure 2Effect of direct TLR2 and TLR4 stimulation on the development and pathogenesis of
IL1rn–/– arthritis.
Treatment of 5-week-old
IL1rn–/– mice with 1 i.p. injection of Pam3Cys (4 mg/kg body weight) or LPS (400 μg/kg body weight) increased the incidence (
A) and the macroscopic severity score (
B) of arthritis. (
C) Histological analysis of the ankle joints at 13 weeks of age expressed as mean ± SEM on a scale from 0 to 3. All parameters were scored by 2 observers blinded to the experimental protocol;
n = 9 mice per group. *
P < 0.05 and **
P < 0.01.
