Sustained pharmacological inhibition of δPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats
J. Clin. Invest. Xin Qi, et al. 118:173 doi:10.1172/JCI32636 [Go to this article.]

Figure 3
Sustained δV1-1 treatment decreases hypertension-induced increases in the permeability of the BBB. Evans blue dye (30 mg/kg) was injected i.v. at 13 weeks of age in rats fed the high-salt diet. The brains were isolated 30 min after injection. (A) Evans blue dye extravasation in DS rats treated with TAT or δV1-1. (B) Quantification of Evans blue dye extravasation in the parenchyma of DS rat brain. Open circles represent the amount of Evans blue dye in individual brains, and the filled circles represent the mean. Data are mean ± SEM (n = 6 rats per group). F = 17.71, df = 2. **P < 0.01 versus TAT treatment groups, ^#P < 0.05 versus rats fed the low-salt diet.