George A. Calin, Carlo M. Croce
J Clin Invest.
2007;
117(8):2059–2066
doi:10.1172/JCI32577
This article Copyright © 2007, The American Society for Clinical Investigation
Abstract
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here is widespread aberrant expression of mature and/or precursor microRNAs in cancer cells, as microRNAs are deregulated consequent to chromosomal alterations and other genomic abnormalities. The identification of such abnormalities has a clear diagnostic and prognostic significance, and there are ever increasing examples of links between certain human cancers and modifications at microRNA loci.
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