JCI - β3-adrenergic receptor activation increases human atrial tissue contractility and stimulates the L-type Ca2+ current

β₃-adrenergic receptor activation increases human atrial tissue contractility and stimulates the L-type Ca²⁺ current

V. Arvydas Skeberdis, Vida Gendvilienė, Danguolė Zablockaitė, Rimantas Treinys, Regina Mačianskienė, Andrius Bogdelis, Jonas Jurevičius, Rodolphe Fischmeister

Published in Volume 118, Issue 9

J Clin Invest. 2008; 118(9):3219–3227 doi:10.1172/JCI32519

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Figure 6

PDE inhibition potentiates the effects of β₃-AR agonists on contractility in human atrial trabeculae.

BRL37344 (A) or CGP12177 (B) were applied to human atrial preparations at the concentrations indicated, in the presence of 200 nM nadolol and in the absence (A) or presence (A and B) of the PDE inhibitor IBMX (10 μM). (C) Summary of the effects of the β₃-AR agonists on contractility. The effects of SR58611 (100 nM), BRL37344 (10 μM), and CGP12177 (1 μM), with or without IBMX (10 μM), are compared with that of ISO (1 μM). The bars show the mean ± SEM of the number of experiments indicated above the bars. *P < 0.05; ***P < 0.005 versus control. ANOVA followed by post-hoc Bonferroni’s test was used to compare the effects of the β₃-AR agonists in the absence or presence of IBMX. ^#P < 0.05.