Distinct KIR/HLA compound genotypes affect the kinetics of human antiviral natural killer cell responses
J. Clin. Invest. Golo Ahlenstiel, et al. 118:1017 doi:10.1172/JCI32400 [
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Figure 3HLA-C–inhibited NK cells of
HLA-C1 homozygous subjects show a stronger increase in CD107a expression after IAV infection than do HLA-C–inhibited NK cells of
HLA-C2 homozygous subjects.
Upregulation of CD107a, a surrogate marker of degranulation and cytotoxicity, is shown at the indicated times after IAV infection of CD3-depleted PBMCs for the total NK cell population (
A) and the HLA-C–inhibited (
B) and HLA-C–noninhibited (
C) NK cell subpopulations. Values are mean ± SEM.
n = 7 per group.
