Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome
J. Clin. Invest. Kamal Rahmouni, et al. 118:1458 doi:10.1172/JCI32357 [Go to this article.]

Figure 5
Comparison of renal SNA, at baseline and in response to leptin, between Bbs2^–/–, Bbs4^–/–, and Bbs6^–/– mice and wild-type littermate controls. (A) Segments of original records of renal SNA at baseline and 4 hours after leptin (5 μg, i.c.v.). (B) Comparison of baseline renal SNA between wild-type and BBS mice (n = 13–37 mice per group). (C) Average renal SNA response 4 hours after leptin administration expressed as a function of time (n = 10–16 mice per group). (D) Average renal SNA response 4 hours after leptin administration expressed as the percentage change from baseline. Data are mean ± SEM. *P < 0.05 compared with wild-type controls.