Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice
J. Clin. Invest. 118:1 doi:10.1172/JCI32273 [Go to this article.]

Figure 5
Wnt5a reduces the number of cells required for functional engraftment in PD mice.

Transplantation of twice the number of VMN cells was required to induce similar behavioral and histological recovery as obtained with VMN-Wnt5a grafts (800,000 and 400,000 cells, respectively). Effects are expressed as changes in rotational behavior (A) and TH⁺ cell counts (B). Data are mean ± SD (n = 3–4 per group). *P < 0.05; **P < 0.01, ANOVA with Tukey post-hoc test.