Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice
J. Clin. Invest. Takashi Nomiyama, et al. 117:2877 doi:10.1172/JCI31986 [
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Figure 6Inflammatory gene expression in adipose tissues from
OPN+/+ and
OPN–/– mice.
OPN+/+ and
OPN–/– mice were fed a LFD or HFD for 25 weeks. mRNA expression levels of the indicated inflammatory genes were analyzed in EWATs isolated from
OPN+/+ (black bars) and
OPN–/– (white bars) mice fed a LFD or
OPN+/+ (dark gray) and
OPN–/– mice (light gray) fed a HFD (
n = 6/group). Data are presented as relative mRNA normalized to TFIIB mRNA and expressed as mean ± SEM. *
P < 0.05, HFD compared with LFD;
#P < 0.05,
OPN–/– mice compared with
OPN+/+ mice fed HFD.
