Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice
J. Clin. Invest. Takashi Nomiyama, et al. 117:2877 doi:10.1172/JCI31986 [
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Figure 3Insulin sensitivity in
OPN+/+ and
OPN–/– mice.
OPN+/+ (black symbols) and
OPN–/– (white symbols) mice were fed a LFD (dashed lines) or HFD (solid lines) for 25 weeks. (
A) Insulin sensitivity in these mice (
n = 6/group) was determined at the end of the feeding period following an intraperitoneal injection of insulin (1 U/kg body weight). (
B) Glucose clearance (
n = 6/group) was analyzed following an intraperitoneal challenge of 1 g/kg body weight glucose. Data are presented as mean blood glucose concentration ± SEM.
#P < 0.05,
OPN–/– compared with
OPN+/+ mice fed HFD.
