Adipocyte LDL receptor–related protein–1 expression modulates postprandial lipid transport and glucose homeostasis in mice
J. Clin. Invest. Susanna M. Hofmann, et al. 117:3271 doi:10.1172/JCI31929 [
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Figure 8Increased energy expenditure and muscle shivering in
ad-Lrp1–/– mice under normal chow–fed conditions.
(
A) Muscle shivering, or fine stationary motor activity, as detected by breaks of the same light beam set in a metabolic cage, where parallel beams were set up close enough so that each mouse had at least 1 light beam being broken by its body. (
B) Cumulative ambulatory movement as measured by breaking of consecutive beams over a 12-hour dark/12-hour light period. Respiratory quotient (
C) and energy expenditure (
D) were recorded in inbred
ad-Lrp1+/+ (blue tracings) and
ad-Lrp1–/– (red tracings) mice. The insets in
A and
D show cumulative fine movement activity and energy expenditure measurements from the respective tracings. Data represent mean ± SEM from 16 mice per group. (
E) Western blots of UCP-1 expression in BAT, UCP-2, and UCP-3 in skeletal muscle of inbred
ad-Lrp1+/+ (lane 1) and
ad-Lrp1–/– (lane 2) mice. *
P < 0.05 and ***
P < 0.0005.
