Inhaled NO accelerates restoration of liver function in adults following orthotopic liver transplantation
J. Clin. Invest. John D. Lang, et al. 117:2583 doi:10.1172/JCI31892 [
Go to this article.]
Figure 3Effects of iNO on ROS and RNS metabolism. (
A) Plasma XOR activities as a function of blood draws during surgery.
†P ≤ 0.05, BD4 relative to BD1 for placebo;
‡P = < 0.001, BD4 relative to BD1 for iNO by repeated-measures ANOVA with Tukey post-hoc analysis. (
B) Changes in hepatocellular expression of XOR (normalized to β-actin) before and 1 hour after reperfusion. (
C) Changes in hepatic expression of eNOS (normalized to β-actin) before and 1 hour after reperfusion.
P values represent significance calculated by paired
t test.
n = 10, placebo;
n = 9, iNO. Inset in
D shows representative Western blots showing changes in eNOS in paired (LB1-LB2) samples from 2 patients in each group. (
D) Average fold change in eNOS expression.
#P ≤ 0.004 relative to placebo.
