Inhaled NO accelerates restoration of liver function in adults following orthotopic liver transplantation
J. Clin. Invest. John D. Lang, et al. 117:2583 doi:10.1172/JCI31892 [
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Figure 2iNO decreases reperfusion-dependent hepatic cell death. (
A) Histopathologic scoring of hepatic tissue samples before (white bars) and 1 hour after reperfusion (black bars).
P values represent significance calculated by paired
t test. (
B) Representative H&E-stained sections indicating increased injury in LB2. Original magnification, ×25. The circled area is shown at a higher magnification (×100) in the inset and shows increased PMN infiltration adjacent to the hepatic vein (zone 3). (
C) Representative fluorescence micrographs showing changes in TUNEL-positive cells (green); blue staining: DAPI. Original magnification, ×25. (
D) Paired changes in TUNEL-positive objects in liver biopsies before (LB1) and 1 hour after reperfusion (LB2).
P values represent significance calculated by paired
t test. (
E) Average reperfusion-dependent increases in TUNEL-positive objects. *
P ≤ 0.0005 relative to placebo.