Inhaled NO accelerates restoration of liver function in adults following orthotopic liver transplantation
J. Clin. Invest. John D. Lang, et al. 117:2583 doi:10.1172/JCI31892 [Go to this article.]

Figure 2
iNO decreases reperfusion-dependent hepatic cell death. (A) Histopathologic scoring of hepatic tissue samples before (white bars) and 1 hour after reperfusion (black bars). P values represent significance calculated by paired t test. (B) Representative H&E-stained sections indicating increased injury in LB2. Original magnification, ×25. The circled area is shown at a higher magnification (×100) in the inset and shows increased PMN infiltration adjacent to the hepatic vein (zone 3). (C) Representative fluorescence micrographs showing changes in TUNEL-positive cells (green); blue staining: DAPI. Original magnification, ×25. (D) Paired changes in TUNEL-positive objects in liver biopsies before (LB1) and 1 hour after reperfusion (LB2). P values represent significance calculated by paired t test. (E) Average reperfusion-dependent increases in TUNEL-positive objects. *P ≤ 0.0005 relative to placebo.