Foxo3 is required for the regulation of oxidative stress in erythropoiesis
J. Clin. Invest. Dragan Marinkovic, et al. 117:2133 doi:10.1172/JCI31807 [
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Figure 3ROS induced shortened erythrocyte lifespan in
Foxo3–/– mice.
(
A) In vivo NAC therapy improves the lifespan of erythrocytes in
Foxo3–/– mice. WT and
Foxo3–/– mice were treated intraperitoneally with NAC (100 mg/kg) or PBS 3 times a week; after 3 weeks, erythrocytes were biotinylated in vivo and erythrocyte lifespan measured as in Figure
2, while NAC (or PBS) treatment continued for another 3 weeks. (
B) Reticulocyte index was measured after 6 weeks in all mice. One of 2 independent experiments is shown. Results represent mean ± SEM,
n = 6 per group; *
P < 0.05.
