Foxo3 is required for the regulation of oxidative stress in erythropoiesis
J. Clin. Invest. Dragan Marinkovic, et al. 117:2133 doi:10.1172/JCI31807 [
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Figure 2Reduced erythrocyte lifespan in
Foxo3–/– mice.
(
A) Erythrocyte lifespan was measured by in vivo biotin labeling. At day 0, 95% of erythrocytes were labeled. Animals were bled every 5 days, and the surviving labeled cells were analyzed by flow cytometry. (
B) Reticulocyte index was measured in
Foxo3–/– and WT mice. Results represent mean ± SEM;
n = 6 in each group. *
P < 0.05, **
P < 0.01, Student’s
t test.
