Valsartan lowers brain β-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease
J. Clin. Invest. Jun Wang, et al. 117:3393 doi:10.1172/JCI31547 [
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Figure 2Chronic valsartan treatment is highly tolerable in Tg2576 mice. Valsartan was provided to female Tg2576 mice from 6 to 11.5 months of age at 10 mg/kg/d or 40 mg/kg/d. (
A and
B) Body weight and fluid consumption were monitored weekly. (
C) Postprandial glucose tolerance response was examined after 5 months of valsartan treatment. (
D) Tg2576 blood pressure measurements in response to approximately 5 months of valsartan treatments. (
E) Baseline measurements of systolic and diastolic blood pressure and mean arterial blood pressure (MAP) in adult female Tg2576 mice and strain-, age-, sex-matched WT mice. The blood pressure determination for each animal was calculated as the mean of 10 individual measurements. Values represents group mean values ± SEM;
n = 7–9 mice per group.
