Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids
J. Clin. Invest. Isabelle M. Berquin, et al. 117:1866 doi:10.1172/JCI31494 [Go to this article.]

Figure 2
Pathological evaluation of prostate. (A) Gross appearance of 8-week-old prostates. (B) Histological evaluation of AP, DL, and VP lobes. Histology was evaluated for the cohort of 180 mice used in Figure 1, but qualitative differences were observed for 8-week-old Pten^P–/– mice when the high–omega-3, low–omega-3, and high–omega-6 diets were compared. Two sections of AP, DL, and VP from each mouse (5 mice per group) were sampled from separate areas of each tissue block and evaluated by 2 veterinary pathologists. When complex histology was found, the most advanced type was indicated. Hyper, hyperplasia; cis, carcinoma in situ; Inv ca, invasive carcinoma. (C) Representative H&E-stained sections from VPs of Pten^P–/– mice. Scale bar: 100 μm. Additional sections are shown in Supplemental Figure 3.