D A Arenberg, M P Keane, B DiGiovine, S L Kunkel, S B Morris, Y Y Xue, M D Burdick, M C Glass, M D Iannettoni, R M Strieter
J Clin Invest.
1998;
102(3):465–472
doi:10.1172/JCI3145
This article Copyright © 1998, The American Society for Clinical Investigation
Abstract
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e report here the role of the CXC chemokine, epithelial neutrophil activating peptide (ENA-78), as an angiogenic factor in human non-small cell lung cancer (NSCLC). In freshly isolated human specimens of NSCLC, elevated levels of ENA-78 were found that strongly correlated with the vascularity of the tumors. In a SCID mouse model of human NSCLC tumorigenesis, expression of ENA-78 in developing tumors correlated with tumor growth in two different NSCLC cell lines. Furthermore, passive immunization of NSCLC tumor-bearing mice with neutralizing anti-ENA-78 antibodies reduced tumor growth, tumor vascularity, and spontaneous metastases, while having no effect on the proliferation of NSCLC cells either in vitro or in vivo. These findings suggest that ENA-78 is an important angiogenic factor in human NSCLC.
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