Figure 2
Effects of homozygous and heterozygous muscle-specific KO of PKC-λ on levels of insulin-sensitive signaling factors and glucose transporters in skeletal and heart muscle.
Muscles were obtained from mice treated as described in Figure 1, A–D. Shown are representative immunoblots of muscle factors from basal and insulin-stimulated WT, heterozygous control, homozygous KO, and heterozygous KO mice. In A, VL and heart muscle of WT and homozygous KO mice, treated with or without insulin were compared. In B, VL and heart muscle of WT and heterozygous KO mice were compared. p-, phosphorylated. See Figure 1 for comparison of aPKC levels amongst groups.
