Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway
J. Clin. Invest. Igor Matushansky, et al. 117:3248 doi:10.1172/JCI31377 [Go to this article.]

Figure 6
Differentiation and transformation via Wnt signaling. MFH cells cultured in ADM (A); ODM (B); ADM, rWnt2, and rWnt5a (C); and ODM, rWnt2, and rWnt5a (D). hMSCs cultured in the absence (E) or presence of hrDkk1 (G); SV40-hMSCLTag cultured in the absence (F) or presence of hrDkk1 (H); tumor volumes at the indicated days of subcutaneously injected SV40-hMSCLTag tumorigenic clones (upper line) and SV40-hMSCLTag cells (lower line) as controls into the flanks of Balb/c nude mice. Clones from H&E staining of tumors formed following subcutaneous injection of in vitro–transformed cells at low (I) and high (J) power. Original magnification, ×200; ×400 (inset).