Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway
J. Clin. Invest. Igor Matushansky, et al. 117:3248 doi:10.1172/JCI31377 [
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Figure 1MFH associated with hMSCs. (
A) Unsupervised hierarchical clustering of a panel of STS (described in detail in ref.
9) using a stem cell gene list (Supplemental Table 1). (
B) Immunohistochemical staining of differentiation-associated proteins on the indicated tumor specimens from a tissue microarray. A single stain representative of 10 tissue samples each of MFH, LS, and leiomyosarcomas (LMS), and of 6 tissue samples each of fibrosarcomas (FS) are shown. Original magnification, ×200.