Figure 7
Effect of imatinib mesylate on pericyte coverage of HT-29 tumors.
HT-29 tumors were double-stained for ECs and pericyte markers. NG2 staining (red) was used as a marker of pericytes or pericyte-like cells, whereas CD31 (blue) was used to identify ECs. There was an increased influx of NG2-positive cells within the PDGF-BB–overexpressing tumors, similar to what was shown previously (Figure 2). This influx was reduced in the imatinib mesylate–treated group, in which pericyte coverage appeared similar to that in control tumors. Representative photomicrographs are shown for each group. Scale bar: 50 μm.
