Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content
J. Clin. Invest. 117:8 doi:10.1172/JCI31334 [Go to this article.]

Figure 6
Effect of imatinib mesylate on tumor growth in vivo.

HT-29 Neo pool and HT-29 S2 cells (1 × 10⁶) were injected subcutaneously into nude mice. Imatinib mesylate was administered daily by oral gavage beginning on day 7. Treatment of PDGF-BB–overexpressing cells with imatinib mesylate increased tumor growth. (A) Volume. (B) Mass. *P < 0.05.