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Paul D. Bieniasz
J Clin Invest. 2007;
117(2):302
doi:10.1172/JCI31290
Abstract |
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H
SCs are one of only a few cell types that resist HIV-1 infection despite the presence of HIV-1 receptors. An increasing number of genes have been identified that can reduce the sensitivity of cultured cells to retrovirus infection, and in this issue of the JCI, Zhang et al. identify p21Waf1/Cip1/Sdi1 (p21) as a gene product that can influence the sensitivity of HSCs to HIV-1 infection (see the related article beginning on page 473). Strikingly, p21 appears to alter the fate of nuclear HIV-1 DNA, promoting the formation of circular viral DNA forms rather than functional proviruses.
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| Title and authors |
Publication |
Year |
CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21
Huabiao Chen, Chun Li, Jinghe Huang, Thai Cung, Katherine Seiss, Jill Beamon, Mary F. Carrington, Lindsay C. Porter, Patrick S. Burke, Yue Yang, Bethany J. Ryan, Ruiwu Liu, Robert H. Weiss, Florencia Pereyra, William D. Cress, Abraham L. Brass, Eric S. Rosenberg, Bruce D. Walker, Xu G. Yu, Mathias Lichterfeld
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J. Clin. Invest.
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2011 |
The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection.
Juliane Haedicke, Craig Brown, Mojgan H Naghavi
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Proc. Natl. Acad. Sci. U.S.A.
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2009 |
Human and simian immunodeficiency viruses deregulate early hematopoiesis through a Nef/PPARγ/STAT5 signaling pathway in macaques
Stéphane Prost, Mikael Le Dantec, Sylvie Augé, Roger Le Grand, Sonia Derdouch, Gwenaelle Auregan, Nicole Déglon, Francis Relouzat, Anne-Marie Aubertin, Bernard Maillere, Isabelle Dusanter-Fourt, Marek Kirszenbaum
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J. Clin. Invest.
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2008 |
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