p21^Cip1 modulates arterial wound repair through the stromal cell–derived factor-1/CXCR4 axis in mice
J. Clin. Invest. Michelle Olive, et al. 118:2050 doi:10.1172/JCI31244 [Go to this article.]

Figure 5
Local vascular p21^Cip1 modulates vascular wound repair. (A) BM transfer experiments were performed between p21^+/+ and p21^–/– mice. Intima/media ratios were measured 2 weeks after vascular injury. The transplantation of p21^+/+ BM into p21^–/– mice (orange bar) decreased arterial lesion formation compared with p21^–/– BM transplanted into p21^–/– mice (light blue bar) (n = 8; *P < 0.05). (B) The percentage of arterial macrophages measured 7 days after injury was decreased in p21^–/– mice that received p21^+/+ BM (orange bar) compared with mice that received p21^–/– BM (light blue bar) (n = 8; ***P < 0.001). This effect was not seen in p21^+/+ mice, where the percentage of arterial macrophages was not different between mice that received p21^+/+ BM (yellow bar) and p21^–/– BM (dark blue bar).