Citations to this article


Neutrophils contain antimicrobial peptides with antituberculous activity, but their contribution to immune resistance to tuberculosis (TB) infection has not been previously investigated to our knowledge. We determined differential white cell counts in peripheral blood of 189 adults who had come into contact with patients diagnosed with active TB in London, United Kingdom, and evaluated them for evidence of TB infection and capacity to restrict mycobacterial growth in whole-blood assays. Risk of TB infection was inversely and independently associated with peripheral blood neutrophil count in contacts of patients diagnosed with pulmonary TB. The ability of whole blood to restrict growth of Mycobacterium bovis bacille Calmette Guérin and Mycobacterium tuberculosis was impaired 7.3- and 3.1-fold, respectively, by neutrophil depletion. In microbiological media, human neutrophil peptides (HNPs) 1–3 killed M. tuberculosis. The neutrophil peptides cathelicidin LL-37 and lipocalin 2 restricted growth of the organism, the latter in an iron-dependent manner. Black African participants had lower neutrophil counts and lower circulating concentrations of HNP1–3 and lipocalin 2 than south Asian and white participants. Neutrophils contribute substantially to innate resistance to TB infection, an activity associated with their antimicrobial peptides. Elucidation of the regulation of neutrophil antimicrobial peptides could facilitate prevention and treatment of TB.


Adrian R. Martineau ... Christopher J. Griffiths, Robert J. Wilkinson


Total citations by year

Year: 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Total
Citations: 1 6 26 22 12 25 16 14 9 1 132
Citation information

Citations to this article (132)

Title and authors Publication Year
Murray and Nadel's Textbook of Respiratory Medicine
PC Hopewell, M Kato-Maeda, JD Ernst
Murray and Nadel's Textbook of Respiratory Medicine 2016
Macrophage defense mechanisms against intracellular bacteria
G Weiss, UE Schaible
Immunological Reviews 2015
New tricks for old dogs: countering antibiotic resistance in tuberculosis with host-directed therapeutics
TR Hawn, JA Shah, D Kalman
Immunological Reviews 2015
Immunological mechanisms contributing to the double burden of diabetes and intracellular bacterial infections
K Hodgson, J Morris, T Bridson, B Govan, C Rush, N Ketheesan
Immunology 2015
Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses
A Lenaerts, CE Barry, V Dartois
Immunological Reviews 2015
Opposite effects of anthelmintic treatment on microbial infection at individual versus population scales
VO Ezenwa, AE Jolles
Science 2015
The onset of adaptive immunity in the mouse model of tuberculosis and the factors that compromise its expression
RT Robinson, IM Orme, AM Cooper
Immunological Reviews 2015
CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis
G Nouailles, A Dorhoi, M Koch, J Zerrahn, JW 3rd, KC Faé, F Arrey, S Kuhlmann, S Bandermann, D Loewe, HJ Mollenkopf, A Vogelzang, C Meyer-Schwesinger, HW Mittrücker, G McEwen, SH Kaufmann
Journal of Clinical Investigation 2014
Antimicrobial peptides and proteins in mycobacterial therapy: Current status and future prospects
A Padhi, M Sengupta, S Sengupta, KH Roehm, A Sonawane
Tuberculosis 2014
Progress in tuberculosis vaccine development and host-directed therapies—a state of the art review
SH Kaufmann, C Lange, M Rao, KN Balaji, M Lotze, M Schito, AI Zumla, M Maeurer
The Lancet Respiratory Medicine 2014
IL-1α and complement cooperate in triggering local neutrophilic inflammation in response to adenovirus and eliminating virus-containing cells
NC di Paolo, LK Baldwin, EE Irons, T Papayannopoulou, S Tomlinson, DM Shayakhmetov
PLoS pathogens 2014
Intracellular Cytokine and Cathelicidin Secretion From Monocytes and Neutrophils in Childhood Tuberculosis:
E Torun, E Cakir, EC Aktas, AH Gedik, G Deniz
The Pediatric Infectious Disease Journal 2014
Early clearance of Mycobacterium tuberculosis : a new frontier in prevention
AJ Verrall, MG Netea, B Alisjahbana, PC Hill, R Crevel
Immunology 2014
Biological Differences Between the Sexes and Susceptibility to Tuberculosis
S Nhamoyebonde, A Leslie
The Journal of Infectious Diseases 2014
Outbreaks of Mycobacterium tuberculosis MDR strains differentially induce neutrophil respiratory burst involving lipid rafts, p38 MAPK and Syk
MM Romero, JI Basile, B López, V Ritacco, L Barrera, MD Sasiain, M Alemán
BMC Infectious Diseases 2014
The lack of a big picture in tuberculosis: the clinical point of view, the problems of experimental modeling and immunomodulation. The factors we should consider when designing novel treatment strategies
C Vilaplana, PJ Cardona
Frontiers in microbiology 2014
Anti-Inflammatory and Antimicrobial Actions of Vitamin D in Combating TB/HIV
AK Coussens, AR Martineau, RJ Wilkinson
Scientifica 2014
Neutrophil gelatinase-associated lipocalin (NGAL) and insulin-like growth factor (IGF)-1 association with a Mannheimia haemolytica infection in sheep
YH Tarazi, MS Khalifeh, MM Al-Kebash, MH Gharaibeh
Veterinary Immunology and Immunopathology 2014
Functional analysis of the mRNA profile of neutrophil gelatinase‑associated lipocalin overexpression in esophageal squamous cell carcinoma using multiple bioinformatic tools
BL Wu, CQ Li, ZP Du, F Zhou, JJ Xie, LW Luo, JY Wu, PX Zhang, LY Xu, EM Li
Molecular medicine reports 2014
Acute myeloid leukemia presenting with pulmonary tuberculosis
M Thomas, M AlGherbawe
Case Reports in Infectious Diseases 2014
The balance between protective and pathogenic immune responses in the TB-infected lung
IM Orme, RT Robinson, AM Cooper
Nature Immunology 2014
Striking the Right Balance Determines TB or Not TB
S BoseDasgupta, J Pieters
Frontiers in immunology 2014
SOCS3 and STAT3, major controllers of the outcome of infection with Mycobacterium tuberculosis
ME Rottenberg, B Carow
Seminars in Immunology 2014
Role for Gr-1+ Cells in the Control of High-Dose Mycobacterium bovis Recombinant BCG
MW Panas, NL Letvin
Clinical and vaccine immunology : CVI 2014
Early clearance of Mycobacterium tuberculosis: a new frontier in prevention
Ayesha J Verrall, Mihai G Netea, Bachti Alisjahbana, Philip C Hill, Reimout van Crevel
Immunology 2014