Advertisement

Citations to this article

Abstract

Neutrophils contain antimicrobial peptides with antituberculous activity, but their contribution to immune resistance to tuberculosis (TB) infection has not been previously investigated to our knowledge. We determined differential white cell counts in peripheral blood of 189 adults who had come into contact with patients diagnosed with active TB in London, United Kingdom, and evaluated them for evidence of TB infection and capacity to restrict mycobacterial growth in whole-blood assays. Risk of TB infection was inversely and independently associated with peripheral blood neutrophil count in contacts of patients diagnosed with pulmonary TB. The ability of whole blood to restrict growth of Mycobacterium bovis bacille Calmette Guérin and Mycobacterium tuberculosis was impaired 7.3- and 3.1-fold, respectively, by neutrophil depletion. In microbiological media, human neutrophil peptides (HNPs) 1–3 killed M. tuberculosis. The neutrophil peptides cathelicidin LL-37 and lipocalin 2 restricted growth of the organism, the latter in an iron-dependent manner. Black African participants had lower neutrophil counts and lower circulating concentrations of HNP1–3 and lipocalin 2 than south Asian and white participants. Neutrophils contribute substantially to innate resistance to TB infection, an activity associated with their antimicrobial peptides. Elucidation of the regulation of neutrophil antimicrobial peptides could facilitate prevention and treatment of TB.

Authors

Adrian R. Martineau ... Christopher J. Griffiths, Robert J. Wilkinson

×

Total citations by year

Year: 2014 2013 2012 2011 2010 2009 2008 2007 Total
Citations: 13 22 13 30 18 14 9 1 120
Citation information

Citations to this article (120)

Title and authors Publication Year
Anti-Inflammatory and Antimicrobial Actions of Vitamin D in Combating TB/HIV
AK Coussens, AR Martineau, RJ Wilkinson
Scientifica 2014
The lack of a big picture in tuberculosis: the clinical point of view, the problems of experimental modeling and immunomodulation. The factors we should consider when designing novel treatment strategies
C Vilaplana, PJ Cardona
Frontiers in microbiology 2014
Outbreaks of Mycobacterium tuberculosis MDR strains differentially induce neutrophil respiratory burst involving lipid rafts, p38 MAPK and Syk
MM Romero, JI Basile, B López, V Ritacco, L Barrera, MD Sasiain, M Alemán
BMC Infectious Diseases 2014
Neutrophil counts in persons of African origin:
CF Thobakgale, T Ndung’u
Current Opinion in Hematology 2014
Outbreaks of Mycobacterium tuberculosis MDR strains differentially induce neutrophil respiratory burst involving lipid rafts, p38 MAPK and Syk
M Romero, J Basile, B López, V Ritacco, L Barrera, M Sasiain, M Alemán
BMC Infectious Diseases 2014
Biological Differences Between the Sexes and Susceptibility to Tuberculosis
S Nhamoyebonde, A Leslie
The Journal of Infectious Diseases 2014
Acute Myeloid Leukemia Presenting with Pulmonary Tuberculosis
M Thomas, M AlGherbawe
Case Reports in Infectious Diseases 2014
Early clearance of Mycobacterium tuberculosis : a new frontier in prevention
AJ Verrall, MG Netea, B Alisjahbana, PC Hill, R Crevel
Immunology 2014
CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis
G Nouailles, A Dorhoi, M Koch, J Zerrahn, JW 3rd, KC Faé, F Arrey, S Kuhlmann, S Bandermann, D Loewe, HJ Mollenkopf, A Vogelzang, C Meyer-Schwesinger, HW Mittrücker, G McEwen, SH Kaufmann
Journal of Clinical Investigation 2014
Antimicrobial peptides and proteins in mycobacterial therapy: Current status and future prospects
A Padhi, M Sengupta, S Sengupta, KH Roehm, A Sonawane
Tuberculosis 2014
Progress in tuberculosis vaccine development and host-directed therapies—a state of the art review
SH Kaufmann, C Lange, M Rao, KN Balaji, M Lotze, M Schito, AI Zumla, M Maeurer
The Lancet Respiratory Medicine 2014
IL-1α and complement cooperate in triggering local neutrophilic inflammation in response to adenovirus and eliminating virus-containing cells
NC di Paolo, LK Baldwin, EE Irons, T Papayannopoulou, S Tomlinson, DM Shayakhmetov
PLoS pathogens 2014
Intracellular Cytokine and Cathelicidin Secretion From Monocytes and Neutrophils in Childhood Tuberculosis:
E Torun, E Cakir, EC Aktas, AH Gedik, G Deniz
The Pediatric Infectious Disease Journal 2014
Differential gene expression of activating Fcγ receptor classifies active tuberculosis regardless of human immunodeficiency virus status or ethnicity
JS Sutherland, AG Loxton, MC Haks, D Kassa, L Ambrose, JS Lee, L Ran, D Baarle, J Maertzdorf, R Howe, H Mayanja-Kizza, WH Boom, BA Thiel, AC Crampin, W Hanekom, MO Ota, H Dockrell, G Walzl, SH Kaufmann, TH Ottenhoff, E Bottieau
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2013
Vitamin D induces interleukin-1β expression: paracrine macrophage epithelial signaling controls M. tuberculosis infection
M Verway, M Bouttier, TT Wang, M Carrier, M Calderon, BS An, E Devemy, F McIntosh, M Divangahi, MA Behr, JH White
PLoS pathogens 2013
Prominent role for T cell-derived Tumour Necrosis Factor for sustained control of Mycobacterium tuberculosis infection
N Allie, SI Grivennikov, R Keeton, NJ Hsu, ML Bourigault, N Court, C Fremond, V Yeremeev, Y Shebzukhov, B Ryffel, SA Nedospasov, VF Quesniaux, M Jacobs
Scientific Reports 2013
Changing world of neutrophils
CI Timár, ÁM Lőrincz, E Ligeti
Pflügers Archiv - European Journal of Physiology 2013
Immune Vulnerability of Infants to Tuberculosis
KV Driessche, A Persson, BJ Marais, PJ Fink, KB Urdahl
Clinical and Developmental Immunology 2013
Role of MHC class Ib molecule, H2-M3 in host immunity against tuberculosis
SA Mir, S Sharma
Vaccine 2013
Polymorphism in cathelicidin gene ( CAMP ) that alters Hypoxia-inducible factor (HIF-1α::ARNT) binding is not associated with tuberculosis
GN Campos, JS Félix, LS Ramírez, SC Salazar, AL Nakamura, GA Tapia, EP de Oca
International Journal of Immunogenetics 2013
Blood Cells and Interferon-Gamma Levels Correlation in Latent Tuberculosis Infection
I Takenami, C Loureiro, A Machado, K Emodi, LW Riley, S Arruda
ISRN Pulmonology 2013
Systems approach to tuberculosis vaccine development: Tuberculosis vaccine development
CC Wang, B Zhu, X Fan, B Gicquel, Y Zhang
Respirology 2013
Blood neutrophil counts in HIV-infected patients with pulmonary tuberculosis: association with sputum mycobacterial load
AD Kerkhoff, R Wood, DM Lowe, M Vogt, SD Lawn
PloS one 2013
B cells regulate neutrophilia during Mycobacterium tuberculosis infection and BCG vaccination by modulating the interleukin-17 response
L Kozakiewicz, Y Chen, J Xu, Y Wang, K Dunussi-Joannopoulos, Q Ou, JL Flynn, SA Porcelli, WR Jacobs, J Chan
PLoS pathogens 2013
A novel assay of antimycobacterial activity and phagocytosis by human neutrophils
DM Lowe, N Bangani, MR Mehta, DM Lang, AG Rossi, KA Wilkinson, RJ Wilkinson, AR Martineau
Tuberculosis 2013

Advertisement
Advertisement