Advertisement

Citations to this article

Abstract

Neutrophils contain antimicrobial peptides with antituberculous activity, but their contribution to immune resistance to tuberculosis (TB) infection has not been previously investigated to our knowledge. We determined differential white cell counts in peripheral blood of 189 adults who had come into contact with patients diagnosed with active TB in London, United Kingdom, and evaluated them for evidence of TB infection and capacity to restrict mycobacterial growth in whole-blood assays. Risk of TB infection was inversely and independently associated with peripheral blood neutrophil count in contacts of patients diagnosed with pulmonary TB. The ability of whole blood to restrict growth of Mycobacterium bovis bacille Calmette Guérin and Mycobacterium tuberculosis was impaired 7.3- and 3.1-fold, respectively, by neutrophil depletion. In microbiological media, human neutrophil peptides (HNPs) 1–3 killed M. tuberculosis. The neutrophil peptides cathelicidin LL-37 and lipocalin 2 restricted growth of the organism, the latter in an iron-dependent manner. Black African participants had lower neutrophil counts and lower circulating concentrations of HNP1–3 and lipocalin 2 than south Asian and white participants. Neutrophils contribute substantially to innate resistance to TB infection, an activity associated with their antimicrobial peptides. Elucidation of the regulation of neutrophil antimicrobial peptides could facilitate prevention and treatment of TB.

Authors

Adrian R. Martineau ... Christopher J. Griffiths, Robert J. Wilkinson

×

Total citations by year

Year: 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Total
Citations: 1 6 26 22 12 25 16 14 9 1 132
Citation information

Citations to this article (132)

Title and authors Publication Year
Murray and Nadel's Textbook of Respiratory Medicine
PC Hopewell, M Kato-Maeda, JD Ernst
Murray and Nadel's Textbook of Respiratory Medicine 2016
Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses
A Lenaerts, CE Barry, V Dartois
Immunological Reviews 2015
Opposite effects of anthelmintic treatment on microbial infection at individual versus population scales
VO Ezenwa, AE Jolles
Science 2015
The onset of adaptive immunity in the mouse model of tuberculosis and the factors that compromise its expression
RT Robinson, IM Orme, AM Cooper
Immunological Reviews 2015
Immunological mechanisms contributing to the double burden of diabetes and intracellular bacterial infections
K Hodgson, J Morris, T Bridson, B Govan, C Rush, N Ketheesan
Immunology 2015
New tricks for old dogs: countering antibiotic resistance in tuberculosis with host-directed therapeutics
TR Hawn, JA Shah, D Kalman
Immunological Reviews 2015
Macrophage defense mechanisms against intracellular bacteria
G Weiss, UE Schaible
Immunological Reviews 2015
Status of vitamin D, antimicrobial peptide cathelicidin and T helper‑associated cytokines in patients with diabetes mellitus and pulmonary tuberculosis
Y Zhan, L Jiang
Experimental and therapeutic medicine 2014
Neutrophil gelatinase-associated lipocalin (NGAL) and insulin-like growth factor (IGF)-1 association with a Mannheimia haemolytica infection in sheep
YH Tarazi, MS Khalifeh, MM Al-Kebash, MH Gharaibeh
Veterinary Immunology and Immunopathology 2014
Tuberculin skin test and interferon-gamma release assay values are associated with antimicrobial peptides expression in  polymorphonuclear cells during latent tuberculous infection
JE Castañeda-Delgado, A Cervantes-Villagrana, CJ Serrano-Escobedo, I Frausto-Lujan, C Rivas-Santiago, JA Enciso-Moreno, B Rivas-Santiago
Memórias do Instituto Oswaldo Cruz 2014
Tuberculin skin test and interferon-gamma release assay values are associated with antimicrobial peptides expression in  polymorphonuclear cells during latent tuberculous infection
JE Castañeda-Delgado, A Cervantes-Villagrana, CJ Serrano-Escobedo, I Frausto-Lujan, C Rivas-Santiago, JA Enciso-Moreno, B Rivas-Santiago
Memórias do Instituto Oswaldo Cruz 2014
Cell-Autonomous Effector Mechanisms against Mycobacterium tuberculosis
JD MacMicking
Cold Spring Harbor Perspectives in Medicine 2014
Anti-Inflammatory and Antimicrobial Actions of Vitamin D in Combating TB/HIV
AK Coussens, AR Martineau, RJ Wilkinson
Scientifica 2014
Apoptotic Neutrophils Augment the Inflammatory Response to Mycobacterium tuberculosis Infection in Human Macrophages
H Andersson, B Andersson, D Eklund, E Ngoh, A Persson, K Svensson, M Lerm, R Blomgran, O Stendahl
PloS one 2014
The balance between protective and pathogenic immune responses in the TB-infected lung
IM Orme, RT Robinson, AM Cooper
Nature Immunology 2014
Striking the Right Balance Determines TB or Not TB
S BoseDasgupta, J Pieters
Frontiers in immunology 2014
The lack of a big picture in tuberculosis: the clinical point of view, the problems of experimental modeling and immunomodulation. The factors we should consider when designing novel treatment strategies
C Vilaplana, PJ Cardona
Frontiers in microbiology 2014
Outbreaks of Mycobacterium tuberculosis MDR strains differentially induce neutrophil respiratory burst involving lipid rafts, p38 MAPK and Syk
MM Romero, JI Basile, B López, V Ritacco, L Barrera, MD Sasiain, M Alemán
BMC Infectious Diseases 2014
Innate Resistance to Tuberculosis in Man, Cattle and Laboratory Animal Models: Nipping Disease in the Bud?
JP Cassidy, AR Martineau
Journal of Comparative Pathology 2014
Neutrophil counts in persons of African origin:
CF Thobakgale, T Ndung’u
Current Opinion in Hematology 2014
Beyond macrophages: the diversity of mononuclear cells in tuberculosis
S Srivastava, JD Ernst, L Desvignes
Immunological Reviews 2014
Intracellular Cytokine and Cathelicidin Secretion From Monocytes and Neutrophils in Childhood Tuberculosis:
E Torun, E Cakir, EC Aktas, AH Gedik, G Deniz
The Pediatric Infectious Disease Journal 2014
IL-1α and complement cooperate in triggering local neutrophilic inflammation in response to adenovirus and eliminating virus-containing cells
NC di Paolo, LK Baldwin, EE Irons, T Papayannopoulou, S Tomlinson, DM Shayakhmetov
PLoS pathogens 2014
Role for Gr-1+ Cells in the Control of High-Dose Mycobacterium bovis Recombinant BCG
MW Panas, NL Letvin
Clinical and vaccine immunology : CVI 2014
CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis
G Nouailles, A Dorhoi, M Koch, J Zerrahn, JW 3rd, KC Faé, F Arrey, S Kuhlmann, S Bandermann, D Loewe, HJ Mollenkopf, A Vogelzang, C Meyer-Schwesinger, HW Mittrücker, G McEwen, SH Kaufmann
Journal of Clinical Investigation 2014

Advertisement
Advertisement