Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID)
J. Clin. Invest. Lilit Garibyan, et al. 117:1550 doi:10.1172/JCI31023 [
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Figure 4TACI self-associates through CRD1 in living cells. (
A) Flow cytometric analysis of 293T cells cotransfected with CFP- or YFP-tagged mTACI and CFP- or YFP-tagged CD40 control. The dual-expressing cells were electronically gated, and more than 20,000 events were acquired into the FRET gate and used for subsequent analysis. (
B) Overlay of FRET plots derived as in
A for interactions between indicated TNFR molecules.
