Prenatal dexamethasone exposure induces changes in nonhuman primate offspring cardiometabolic and hypothalamic-pituitary-adrenal axis function
J. Clin. Invest. Annick de Vries, et al. 117:1058 doi:10.1172/JCI30982 [Go to this article.]

Figure 1
Intravenous glucose tolerance tests in offspring of dexamethasone- and control-treated pregnancies. (A–C) Plasma glucose levels before (time = 0) and during an i.v. glucose tolerance test. Overall glucose clearance was affected by antenatal dexamethasone treatment (2-way ANOVA, F_(3,244) = 4.4, P = 0.005). The glucose clearance was slower in the dex120 and dex200 offspring than in controls (post hoc testing, Fisher’s least significant difference method for factor, *P < 0.02 for dex120 and dex200; P = 0.051 for dex50). (D) Insulin levels of 8-month-old offspring before and 10 minutes after i.v. glucose administration. Basal insulin levels were increased in dex120 offspring (^†P < 0.05 versus control; 2-tailed Student’s t test). At 10 minutes, plasma insulin was elevated in dex120 and dex200 offspring (^†P < 0.05 versus control; 2-tailed Student’s t test).