Paul S. Frenette, George F. Atweh
J Clin Invest.
2007;
117(4):850–858
doi:10.1172/JCI30920
This article Copyright © 2007, The American Society for Clinical Investigation
Abstract
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T
he discovery of the molecular basis of sickle cell disease was an important landmark in molecular medicine. The modern tools of molecular and cellular biology have refined our understanding of its pathophysiology and facilitated the development of new therapies. In this review, we discuss some of the important advances in this field and the impediments that limit the impact of these advances.
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