JCI - Sickle cell disease: old discoveries, new concepts, and future promise

Sickle cell disease: old discoveries, new concepts, and future promise

Paul S. Frenette, George F. Atweh

Published in Volume 117, Issue 4

J Clin Invest. 2007; 117(4):850–858 doi:10.1172/JCI30920

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Figure 1

Sickle erythrocytes.

Peripheral blood smear from a patient with SCD obtained during a routine clinic visit. The smear shows classical sickle-shaped (arrows) and various other misshaped erythrocytes (arrowheads). The image was obtained from an air-dried smear using differential interference contrast (DIC) microscopy with an Olympus BX61WI work station equipped with a LUMPlanFI ×60 numerical aperture 0.90 ∞ objective (Olympus) and a CoolSnap HQ camera (6.6 μm² pixel, 1,392 × 1,040 pixel format) (Roper Scientific). Scale bar: 10 μm.