Constitutive IKK2 activation in acinar cells is sufficient to induce pancreatitis in vivo
J. Clin. Invest. Bernd Baumann, et al. 117:1502 doi:10.1172/JCI30876 [
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Figure 5Activation of trypsin in acini is independent of IKK2-DN and IKK2-CA expression. Differential interference contrast and rhodamine-110 fluorescence images were collected throughout the equilibration period of isolated acini from wild-type, Ela.rtTA×IKK2-DN, and Ela.rtTAxIKK2-CA mice and after stimulation with supramaximal cerulein in vitro. Shown is quantitative evaluation of the relative fluorescence increase at the apical pole of at least 8 measurements for each genotype. Differences were not significant at 10, 20, and 30 minutes.
