Figure 3
Effect of PM on thrombin generation and arterial thrombosis.
(A) Plasma levels of TAT complexes in PM- and PBS-treated mice. (B–D) Time to occlusion of the carotid artery after the application of FeCl3. (B) Representative 2D ultrasound view of the common carotid artery (CCA) and aorta (Ao) and Doppler from CCA before and after application of FeCl3 (at the time of cessation of blood flow). Loss of blood flow detected via Doppler was also associated with dilation of CCA. (C) Representative histology of CCA after FeCl3 injury showing a large thrombus with almost complete occlusion of arterial lumen (original magnification, ×200). (D) Time to loss of carotid blood flow in PM- or PBS-treated mice. *P < 0.05 for comparison between PM- and PBS-treated mice, n ≥ 4 in each treatment group.
