IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system
J. Clin. Invest. Shoji Sanada, et al. 117:1538 doi:10.1172/JCI30634 [Go to this article.]

Figure 4
IL-33/ST2 signaling is cardioprotective in vivo. (A) Representative H&E and Sirius red stains and (B) quantitative analyses of samples from each group. Computer-based image analysis was used for measurements. ST2^–/– mice developed more cardiomyocyte hypertrophy and cardiac fibrosis after TAC than did WT mice. Furthermore, treatment with IL-33 (2 μg/d i.p.) significantly improved these changes in WT mice, but not in ST2^–/– mice. C, nonoperated control. Scale bar: 10 μm. (C) Gross measurement of heart weight normalized to body weight was consistent with the histomorphometric analyses. *P < 0.05 versus nonoperated control (B) or sham-operated WT (C); ^ΧP < 0.05 versus the same treatment in WT; ^†P < 0.05 versus sham in the same group; ^#P < 0.05.