Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III
J. Clin. Invest. Wolfgang Bergmeier, et al. 117:1699 doi:10.1172/JCI30575 [Go to this article.]

Figure 5
CalDAG-GEFI regulates neutrophil extravasation. (A) TG-induced peritonitis. Infiltrating leukocytes were isolated from the peritoneum of WT and CalDAG-GEFI^–/– mice 4 hours after injection of PBS or 3% TG. Neutrophil counts were determined by morphological analyses of Diff-Quik–stained cytocentrifuge preparations by an observer blinded to the genotype. (B) Croton oil–induced dermatitis. Ears of WT and CalDAG-GEFI^–/– mice were painted with croton oil, and infiltrating neutrophils were counted 6 hours later in H&E-stained ear sections. Few neutrophils were found in vehicle-treated ears. n = 3–5. ***P < 0.001.