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The role of CXC chemokines in pulmonary fibrosis
Robert M. Strieter, Brigitte N. Gomperts, Michael P. Keane
Published in Volume 117, Issue 3
J Clin Invest. 2007; 117(3):549–556 doi:10.1172/JCI30562
This article Copyright © 2007, The American Society for Clinical Investigation
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Figure 4
The role of the CXCL12-CXCR4 biological axis in fibrocyte extravasation in pulmonary fibrosis.

Lung-derived factors (such as GM-CSF, G-CSF, and M-CSF) generated under conditions of lung injury communicate with the BM to expand the number of fibrocytes in the BM and to mobilize fibrocytes that express CXCR4 into the circulation. CXCR4-expressing fibrocytes traffic through the circulation and extravasate into the lung in response to the CXCR4 ligand CXCL12, which is produced during the pathogenesis of fibrosis.

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