Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model
J. Clin. Invest. Christophe Dubois, et al. 117:953 doi:10.1172/JCI30537 [Go to this article.]

Figure 7
Effect of lepirudin on platelet accumulation and fibrin deposition in WT mice. Thrombus formation was induced as described in Figure 1, and platelets and fibrin detected using Fab fragments of antibodies against CD41 and fibrin-specific antibodies, respectively. The median integrated fluorescence over time is presented for 30 thrombi generated in 3 WT mice. After generating a series of 10 thrombi per mouse, lepirudin (8 U/g mouse) was infused and 9–10 additional thrombi generated per mouse. A total of 28 thrombi before infusion and 29 thrombi after infusion were studied in 3 mice. Black, before infusion; gray, after infusion.